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KMID : 1189420150280030001
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2015 Volume.28 No. 3 p.1 ~ p.13
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Study on the Anti-inflammatory Effects of the Remedy Prescripted with Lonicera japonica and Scutellaria baicalensis Radix in U937 cells
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Lee Young-Sook
Jung Myung
Lim Kyu-Sang
Yoon Yong-Gab
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Abstract
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Objective : This study investigated the inflammatory reaction is characterized by over production of inflammatory mediators due to an up-regulation of inflammatory pathways.
Methods : We investigated the anti-inflammatory effects of water extracts fromLonicera japonicaandScutellaria baicalensisin lipopolysaccharide (LPS)-stimulated U937 cells. Each extract suppressed the production of inflammatory mediators (NO, IL-1β, TNF-β, and PGE2) and the expression of inducible NO synthase and cyclooxygenase-2 in LPS- stimulated U937 cells in a dose-dependent manner.
Results : These suggest that the suppression effects were synergistically increased by their combination. Their combination extract also inhibited NF-κB-DNA complex of NF-κB binding activity and translocation of NF-κB from cytosol to nucleus.
Conclusions : Our study suggest that the combination of water-extractable components ofL. japonicaandS. baicalensismay be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.
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KEYWORD
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Lonicera japonica, Scutellaria baicalensis, Tumor necrosis factor-alpha(TNF-α), prostaglandin E2(PGE2), nitric oxide(NO)
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